Dysreguation of species-specific GDNF and GDNFOS isoforms in human temporal girus of Alzheimer’s disease and rat nucleus accumbens of heroin withdrawal
نویسندگان
چکیده
Abbreviations: GDNF, Glial cell line-derived neurotrophic factor; GDNFOS, GDNF opposite strand; BDNFOS, BDNF opposite strand; NAT, natural antisense transcripts; AD, Alzheimer’s disease; HD, Huntington’s disease; CON, control; MTG, middle temporal gyrus; EST, expressed sequence tags; UTR, un-translated region of mRNA; RT-qPCR, reverse transcription – quantitative polymerase chain reaction; MGB, DNA minor grove binding protein; Ct, cycle threshold; ORF, open reading frame; DNSP-11, dopamine neuron stimulating peptide-11;
منابع مشابه
The Effect of Nitric Oxide Microinjection in Nucleus Accumbens Shell on Morphine Withdrawal Signs in Male Rats
Introduction: This study was performed to evaluate the effects of intra-nucleus accumbens shell microinjection of Larginine (NO precursor) and L-NAME (nitric oxide synthase (NOS) inhibitor) on morphine withdrawal signs in male rats. Method: Rats were anaesthetized with a combination of ketamine and xylazine, and placed in stereotaxic apparatus, and a guide cannula was inserted into nucleus accu...
متن کاملExogenous sodium hydrosulfide can attenuate naloxone-precipitated withdrawal syndromes and affect cAMP signaling pathway in heroin-dependent rat's nucleus accumbens.
BACKGROUND H2S is a novel type of endogenous neural regulatory factor and gaseous mediator. Exogenous H2S can increase heroin-induced learning and memory damage in rat and alleviates heroin-induced rat hippocampus damage through antioxidant and anti-apoptosis effects. OBJECTIVE Aim of this study was to identify whether hydrogen sulfide (H2S) protects heroin withdrawal rat is related with aden...
متن کاملGlutamate Receptors in Nucleus Accumbens Can Modulate Canabinoid-Induced Antinociception in Rat’s Basolateral Amygdala
Introduction: It has been shown that administration of WIN55,212-2, a cannabinoid receptor agonist, into the basolateral amygdala (BLA), dose-dependently increases the thermal latency to withdrawal in the tail-.ick test and decreases pain related behaviors in both phases of the formalin test. Recent human and animal imaging data suggest that the nucleus accumbens (NAc) is an important neural su...
متن کاملExpression of brain-derived neurotrophic factors, neurotrophin-3, and neurotrophin-4 in the nucleus accumbens during heroin dependency and withdrawal
Neurotrophins, brain-derived neurotrophic factors (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4), have been implicated in the modulation of heroin dependency. This study was designed to explore the expression alterations of BDNF, NT-3, and NT-4 in the context of heroin dependence and withdrawal in the rat nucleus accumbens (NAc). Heroin dependence was induced by a progressive intraper...
متن کاملEffect of morphine on apoptotic factors caspase-3, PARP and Bax/Bcl-2 ratio in nucleus accumbens in conditioned place preference model in rat
Introduction: Nucleus accumbens (NAc) plays a critical role in neuronal reward circuits that are responsible for motivated and goal-directed behaviors. Some data suggest that morphine induces apoptosis in neurons, while other evidences show that morphine could have beneficial effects against neuronal cell death. This study was designed to evaluate the effect of morphine on apoptosis in the N...
متن کامل